This is my go-to pattern for variegated or self-striping sock yarn with contrasting heels and toes. The construction is cuff-down, with an eye of partridge heel and anatomically correct toes (for those of us with more angled toes) - so this pattern will result in defined left and right socks. The pattern is written for two circular needles, but if you have some experience with sock knitting, feel free to use the needle of your choice.

Ingredients:
Main color yarn: any fingering weight sock yarn, 250-350 yards
Contrasting color yarn: any fingering/heavy fingering weight sock yarn, approx. 50-60 yards
(Your yarn mileage will really vary here, depending on how long you like your sock leg, how long your feet are, etc. One 100g skein of sock yarn (400-437 yards) will typically be enough to make a pair of regular length women’s socks, accounting for some variation in foot length. I wear a US 7.5 and usually use about 250 yards of MC yarn.)
Needles: two 16” circular needles in US 1 or 1.5 (2.25 or 2.5 mm), or as needed to get gauge
Crochet hook (optional)
Tapestry needle

Suggested gauge:
32 stitches x 40 rounds = 4”/10cm worked in stockinette stitch